MICROPHOTOCOAGULATION - SELECTIVE EFFECTS OF REPETITIVE SHORT LASER-PULSES

被引:168
作者
ROIDER, J
HILLENKAMP, F
FLOTTE, T
BIRNGRUBER, R
机构
[1] UNIV MUNSTER,INST MED PHYS & BIOPHYS,D-48149 MUNSTER,GERMANY
[2] MED LASER CTR GMBH,D-23562 LUBECK,GERMANY
[3] MED UNIV LUBECK,AUGENHEILKUNDE KLIN,D-23538 LUBECK,GERMANY
关键词
D O I
10.1073/pnas.90.18.8643
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Repetitive exposure to short laser pulses is shown to cause selective damage to absorbing structures (cells, organelles, or enzymes) with pulse energies below the threshold energy for single-pulse damage. Directly adjacent structures are spared in vivo. Additivity of (presumably nonphotochemical) subthreshold effects is demonstrated. Selective damage to the retinal pigment epithelium with sparing of the neural retina is shown (514 nm, 5 mus, 1-500 pulses at 500 Hz, 2- to 10-muJ pulse energy). A melanin granule model has been developed and applied to the experimental situation. Histological results as well as the basic mechanism for these effects are discussed.
引用
收藏
页码:8643 / 8647
页数:5
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