EFFECTS OF LIPOSOME-ENTRAPPED ADENOSINE IN THE ISOLATED RAT AORTA

被引：8

作者：

BRAILOIU, E ^{[1
]}

SERBAN, DN ^{[1
]}

SLATINEANU, S ^{[1
]}

FILIPEANU, CM ^{[1
]}

PETRESCU, BC ^{[1
]}

BRANISTEANU, DD ^{[1
]}

机构：

[1] UNIV MED & PHARM IASI,DEPT PHYSIOL,R-6600 IASI,ROMANIA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 250卷 / 03期

关键词：

LIPOSOME; ADENOSINE; SMOOTH MUSCLE; VASCULAR;

D O I：

10.1016/0014-2999(93)90040-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study examined the effects of adenosine- and adenosine deaminase loaded liposomes upon the contractile activity of the vascular smooth muscle, using the isolated, de-endothelised rat aorta ring as in vitro model. While control liposomes had no effect, intraliposomal adenosine (5X10(-3) M) induced contraction of the preparation. Intraliposomal adenosine deaminase induced partial relaxation of high K+-precontracted rings. The adenosine-induced contraction seems to involve Ca2+ influx through L-type channels as an essential component, but protein kinase C may also have a modulatory role.

引用

页码：489 / 492

页数：4

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