HIGH-GRADE B-CELL CEREBRAL LYMPHOMA IN A PATIENT WITH ANTI-MYELIN-ASSOCIATED GLYCOPROTEIN IGM PARAPROTEINEMIC NEUROPATHY

被引：11

作者：

ELLIE, E

VITAL, A

STECK, AJ

JULIEN, J

HENRY, P

VITAL, C

机构：

[1] UNIV HOSP BORDEAUX,DEPT NEUROL,BORDEAUX,FRANCE

[2] UNIV HOSP BORDEAUX,DEPT NEUROPATHOL,BORDEAUX,FRANCE

[3] KANTONSSPITAL BASEL,DEPT NEUROL,BASEL,SWITZERLAND

来源：

NEUROLOGY | 1995年 / 45卷 / 02期

关键词：

D O I：

10.1212/WNL.45.2.378

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 74-year-old woman with a sensory neuropathy and IgM M-protein monoclonal gammopathy of undetermined significance developed a fatal B-cell cerebral lymphoma. CSF protein immunofixation revealed intrathecal secretion of a paraprotein of the same heavy- and light-chain isotypes as the serum monoclonal component (IgM-lambda). Reactivation of Epstein-Barr virus was present in the lymphoma cells. Different factors may be involved in the preferential malignant development of the monoclonal B-cell clone within the CNS.

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页码：378 / 381

页数：4

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