THE K-ATP BLOCKER SODIUM 5-HYDROXYDECANOATE DOES NOT ABOLISH PRECONDITIONING IN ISOLATED RAT HEARTS

被引：29

作者：

GROVER, GJ

MURRAY, HN

BAIRD, AJ

DZWONCZYK, S

机构：

[1] Department of Pharmacology, Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543-4000

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 277卷 / 2-3期

关键词：

MYOCARDIAL ISCHEMIA; K+ CHANNEL; ATP-SENSITIVE; PRECONDITIONING;

D O I：

10.1016/0014-2999(95)00111-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Blockers of ATP-sensitive K+ channels (K-ATP) abolish preconditioning in several species. Glyburide does not abolish preconditioning in rat hearts, but this may be due to a loss of its activity during ischemia. We determined the effect of a K-ATP blocker, which is more active during ischemia (sodium 5-hydroxydecanoate, 5-HD), on preconditioning in isolated rat hearts. Rat hearts were subjected to 4 periods of 5 min global ischemia followed by 30 min of global ischemia and reperfusion. Preconditioning significantly enhanced post-ischemic recovery of function and reduced lactate dehydrogenase (LDH) release vs. sham. 5-HD (100 mu M) did not abolish preconditioning. Cromakalim (20 mu M) was protective in this ischemic model and this was abolished by 5-HD. This is further evidence that K-ATP opening is not the mechanism of preconditioning in rats.

引用

页码：271 / 274

页数：4

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