INTRASTRIATAL ANGIOTENSIN-II INDUCES TURNING BEHAVIOR IN 6-HYDROXYDOPAMINE LESIONED RATS

被引：16

作者：

JENKINS, TA

CHAI, SY

HOWELLS, DW

MENDELSOHN, FAO

机构：

[1] Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, 3084 Vic., Austin Campus

来源：

BRAIN RESEARCH | 1995年 / 691卷 / 1-2期

关键词：

ANGIOTENSIN II; DOPAMINE; ROTATION; LOSARTAN; STRIATUM; SUBSTANTIA NIGRA; HALOPERIDOL;

D O I：

10.1016/0006-8993(95)00677-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In rats with unilateral 6-hydroxydopamine lesions in the nigrostriatal pathway, injection of angiotensin II (2 nmol) into the unlesioned striatum elicited dose-related tight rotations ipsilateral to the lesion. This rotation was suppressed by coadministration of the angiotensin AT(1) receptor antagonist, losartan (2 nmol), which had no significant effect when injected alone. Preadministration of the dopamine antagonist, haloperidol (2 mg/kg i.p.) completely blocked angiotensin II-induced turning at doses of 0.3-3 nmol, and partially at 10 nmol. These results further confirm the hypothesis that Ang II is intrinsically involved in modulating dopamine release in the striatum, an effect which is mediated predominantly by AT(1) receptors.

引用

页码：213 / 216

页数：4

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