AEROSOL INHALATION IN THE RAT LUNG .2. THEORETICAL PREDICTIONS OF PARTICLE DEPOSITION PATTERNS

被引：14

作者：

KOBLINGER, L

HOFMANN, W

机构：

[1] Health Physics Department, KFKI Atomic Energy Research Institute, H-1525 institute Budapest

[2] Institute of Physics and Biophysics, University of Salzburg, A-5020 Salzburg

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1995年 / 8卷 / 01期

关键词：

RAT; LUNG; DEPOSITION; MODEL;

D O I：

10.1089/jam.1995.8.21

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Theoretical predictions of total, regional and local deposition fractions of inhaled particles are based on the complete stochastic model of the rat lung presented in Part I (Koblinger et al., 1995). Deposition patterns of inhaled particles ranging from 0.01 to 10 mu m diameter are computed for two stochastic rat lung models differing only in their respective tracheobronchial morphometries. Deposition fractions based on the two stochastic morphometric models are compared to corresponding results utilizing the deterministic lung model of Yeh et al. (1979) as well as to the available experimental evidence. In contrast to the simulations with the presently used deterministic model of the rat lung and our previous stochastic model of the human lung, the differential distributions of deposited matter throughout the rat airway system are expressed as functions of the airway diameter, which permits a more realistic description of the rather monopodial structure of the rat lung.

引用

页码：21 / 32

页数：12

共 31 条

[1]

BALASHAZY I., HOFMANN W., Particle deposition in airway bifurcations I, Inspiratory flow. J. Aerosol Sci., 24, pp. 745-772, (1993)

[2]

BALASHAZY I., HOFMANN W., Particle deposition in airway bifurcations II, Expiratory flow. J. Aerosol Sci., 24, pp. 773-786, (1993)

[3]

BALASHAZY I., HOFMANN W., Deposition of Aerosols in asymmetric airway bifurcations, J. Aerosol Sci. (in press)., (1994)

[4]

BAILEY M.R., BIRCHALL A., CUDDIHY R.G., JAMES A.C., ROY M., Respiratory tract clearance model for dosimetry and bioassay of inhaled radionuclides, Radial Prot. Dosim., 38, pp. 153-158, (1991)

[5]

CHAN T.L., LEE P.S., HERING W.R., Deposition and clearance of inhaled diesel particles in the respiratory tract of Fischer rats, J. Appi Toxicol, 1, pp. 77-82, (1981)

[6]

CHENG Y.S., HANSEN G.K., SU Y.F., YEH H.C., MORGAN K.T., Deposition of ultraiine aerosols in rat nasal molds, Toxicol Appi Pharmacol, 106, pp. 222-233, (1990)

[7]

COSTA D.L., TEPPER J., Approaches to lung function assessment in small mammals, pp. 43-70, (1988)

[8]

HANSEN J.E., AMPAYA E.P., Human air space shapes, sizes, areas, and volumes, J. Appi. Physiol, 38, pp. 990-995, (1975)

[9]

HOFMANN W., KOBLINGER L., MARTONEN T.B., Structural differences between human and rat lungs: implications for Monte Carlo modeling of aerosol deposition, 1, pp. 41-47, (1989)

[10]

HOFMANN W., KOBLINGER L., Monte Carlo modeling of aerosol deposition in human lungs, Part II: deposition fractions and their sensitivity to parameter variations. J. Aerosol Sci., 21, pp. 675-688, (1990)

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