RELATIONSHIP BETWEEN REPRESSION OF DIMETHYLNITROSAMINE-DEMETHYLASE BY POLYCYCLIC AROMATIC-HYDROCARBONS AND THEIR SHAPE

被引：26

作者：

KALISZAN, R

LAMPARCZYK, H

RADECKI, A

机构：

[1] Department of Physical Chemistry, Medical Academy, 80-416 Gdańsk

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 01期

关键词：

D O I：

10.1016/0006-2952(79)90279-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The quantitative relationship between the ability of polycyclic aromatic hydrocarbons to repress the mixed-function oxidase, dimethylnitrosamine-demethylase, and a parameter expressing the shape of the hydrocarbon molecules, has been studied. The shape parameter represents the ratio of the longer to shorter sides of the minimum rectangular envelope around the structure, drawn proportionally to atomic dimensions. The shape parameter allows the prediction of the relative biological activity of 23 active and 4 inactive compounds. © 1979.

引用

页码：123 / 125

页数：3

共 8 条

[1]

ARCOS JC, 1961, J BIOL CHEM, V236, P1291

[2] DIMETHYLNITROSAMINE-DEMETHYLASE - MOLECULAR SIZE-DEPENDENCE OF REPRESSION BY POLYNUCLEAR HYDROCARBONS - NON-HYDROCARBON REPRESSORS [J].