CHEMISTRY OF CEPHALOSPORIN ANTIBIOTICS .14. REACTION OF CEPHALOSPORIN-C WITH NITROSYL CHLORIDE

被引：50

作者：

MORIN, RB

JACKSON, BG

FLYNN, EH

ROESKE, RW

ANDREWS, SL

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1969年 / 91卷 / 06期

关键词：

D O I：

10.1021/ja01034a022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interaction of cephalosporin C with nitrosyl chloride was examined in detail. In addition to 7-aminocephalosporanic acid (7-ACA, lb), the 7-chlorocephalosporanic acid was isolated as its methyl ester (5). Three substances resulting from intermolecular reactions of the intermediate 3 were isolated and characterized (7a, 7b, and 7c). α-Hydroxyadipic acid and its lactone were obtained in yields corresponding to those products resulting from intramolecular reactions. © 1969, American Chemical Society. All rights reserved.

引用

页码：1396 / &

共 24 条

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