NEUROTRANSMITTER-RELATED ENZYMES IN SENILE DEMENTIA OF THE ALZHEIMER TYPE

被引：611

作者：

DAVIES, P

机构：

[1] Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx

来源：

BRAIN RESEARCH | 1979年 / 171卷 / 02期

关键词：

D O I：

10.1016/0006-8993(79)90336-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) activities were measured in 20 brain regions from autopsied control and senile dementia of the Alzheimer type (SDAT) cases. Large, widespread reductions in the activities of ChAT and AChE were found in tissues from SDAT cases, while GAD activities were reduced in 3 of the 20 regions investigated. AChE activity in cerebrospinal fluid from SDAT cases was similar to that found in samples from non-demented patients. © 1979.

引用

页码：319 / 327

页数：9

共 25 条

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ADOLFSSON R, 1978, ALZHEIMERS DISEASE S

[2] NEUROTRANSMITTER-RELATED ENZYMES AND INDEXES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES [J].