ACUTE OR CHRONIC ANTIDEPRESSANTS DO NOT MODIFY [I125]CYANOPINDOLOL BINDING TO 5-HT1B RECEPTORS IN RAT-BRAIN

被引：18

作者：

MONTERO, D

DEFELIPE, MC

DELRIO, J

机构：

[1] UNIV NAVARRA, SCH MED, DEPT PHARMACOL, E-31080 PAMPLONA, SPAIN

[2] CSIC, CAJAL INST, DEPT NEUROPHARMACOL, MADRID 6, SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 196卷 / 03期

关键词：

5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); 5-HT1B RECEPTORS; ANTIDEPRESSANTS;

D O I：

10.1016/0014-2999(91)90448-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acute or chronic treatment of young or adult rats with chlorimipramine, tianeptine or iprindole, antidepressants with different effects on 5-HT uptake mechanisms, did not modify the density or the affinity of 5-HT1B receptors of the frontal cortex. No significant receptor change was found after prenatal exposure to these antidepressants. The lack of effect of the antidepressants was not related to the density of 5-HT1B receptors, which was significantly lower in younger animals.

引用

页码：327 / 329

页数：3

共 10 条

[1]

DELRIO J, 1988, PROG BRAIN RES, V73, P173

[2] IDENTITY OF INHIBITORY PRESYNAPTIC 5-HYDROXYTRYPTAMINE (5-HT) AUTORECEPTORS IN THE RAT-BRAIN CORTEX WITH 5-HT1B BINDING-SITES [J].