LYSOLECITHIN AS REGULATOR OF DENOVO LECITHIN SYNTHESIS IN RAT-LIVER MICROSOMES

被引：23

作者：

PARTHASARATHY, S

BAUMANN, WJ

机构：

[1] The Hormel Institute, University of Minnesota, Austin

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91569-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1-Acyl-sn-glycero-3-phosphocholine (lysolecithin) was found to affect 1,2-diacyl-sn-glycerol:CDPcholine cholinephosphotransferase (CPT; EC 2.7.8.2) activity of rat liver microsomes in a concentration dependent, characteristic manner. Cholinephosphate transfer was activated at lysolecithin concentrations below 0.5 mM with a maximum stimulation occurring at 75-100 μM lysolecithin levels. At concentrations above 0.5 mM, CPT activity was inhibited by lysolecithin. It was shown that CPT inhibition by lysolecithin is competitive (Ki ≈ 0.6 mM) with respect to CDPcholine. The possible role of lysolecithin as regulator of de novo lecithin synthesis in vivo is outlined. © 1979.

引用

页码：637 / 642

页数：6

共 20 条

[1]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[2]

CHOY PC, 1978, J BIOL CHEM, V253, P5163

[3] EVIDENCE THAT BIOSYNTHESIS OF PHOSPHATIDYLETHANOLAMINE, PHOSPHATIDYLCHOLINE, AND TRIACYLGLYCEROL OCCURS ON CYTOPLASMIC SIDE OF MICROSOMAL VESICLES [J].