THE INHIBITORY EFFECTS OF OLIGONUCLEOTIDES, COMPLEMENTARY TO MAREKS-DISEASE VIRUS MESSENGER-RNA TRANSCRIBED FROM THE BAMHI-H REGION, ON THE PROLIFERATION OF TRANSFORMED LYMPHOBLASTOID-CELLS, MDCC-MSB1

被引：41

作者：

KAWAMURA, M

HAYASHI, M

FURUICHI, T

NONOYAMA, M

ISOGAI, E

NAMIOKA, S

机构：

[1] HOKKAIDO UNIV,FAC VET MED,DEPT LAB ANIM SCI,SAPPORO,HOKKAIDO 060,JAPAN

[2] TAMPA BAY RES INST,DEPT VIROL,ST PETERSBURG,FL 33716

[3] HIGASHI NIPPON GAKUEN UNIV,SCH DENT,DEPT PREVENT DENT,TOBETSU 069,JAPAN

来源：

JOURNAL OF GENERAL VIROLOGY | 1991年 / 72卷

关键词：

D O I：

10.1099/0022-1317-72-5-1105

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An oligonucleotide complementary to the splice donor sequence of the 1.8 kb gene family produced from the BamHI-H region of Marek's disease virus (MDV) DNA inhibited the proliferation of the MDV-derived lymphoblastoid cell line, MDCC-MSB1 (MSB-1), but not that of the avian lymphoid leukosis-derived lymphoblastoid cell line, LSCC-BK3. Colony formation in soft agar was also inhibited by treatment of MSB-1 cells with the antisense oligonucleotide. It is hypothesized that expression of the 1.8 kb gene family produced from the BamHI-H region is directly associated with the maintenance of the tumorigenic state of transformed Marek's disease-derived lymphoblastoid cells.

引用

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页码：1105 / 1111

页数：7

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