PREDICTION OF SERUM VANCOMYCIN CONCENTRATIONS FOLLOWING INTRAPERITONEAL LOADING DOSES IN CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS PATIENTS WITH PERITONITIS

被引:20
作者
BAILIE, GR
EISELE, G
VENEZIA, RA
YOCUM, D
HOLLISTER, A
机构
[1] UNION UNIV,DIV NEPHROL,ALBANY,NY 12208
[2] UNION UNIV,DEPT PATHOL & LAB MED,ALBANY,NY 12208
[3] ALBANY MED CTR HOSP,HOME DIALYSIS UNIT,ALBANY,NY 12208
关键词
D O I
10.2165/00003088-199222040-00005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pharmacokinetics of vancomycin were studied in continuous ambulatory peritoneal dialysis patients with peritonitis. Six patients received an intraperitoneal loading dose of 15 mg/kg and 4 received an intraperitoneal dose of 25 mg/L. The ability of 2 methods to predict serum concentrations during the loading dose exchange was determined. The mean serum concentration after the exchange was 17.8 +/- 2.2 mg/L in patients receiving the loading dose. The mean dialysis clearance in all patients was 0.94 +/- 0.34 L/h. 66.6 +/- 13.4% of a dose was absorbed into the circulation in 4h. The volume of distribution was 0.61 +/- 0.46 L/kg, and the half-life for equilibration of vancomycin into the circulation from dialysate was 2.76 +/- 0.94h. Two methods of predicting serum vancomycin concentrations were tested, with 1 method predicting values significantly different from measured concentrations while the other did not. Serum vancomycin concentrations can be accurately predicted during a loading dose exchange.
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页码:298 / 307
页数:10
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