ENZYME-CATALYZED SYNTHESIS OF OPTICALLY PURE BETA-SULFONAMIDOPROPIONIC ACIDS - USEFUL STARTING MATERIALS FOR P-3 SITE MODIFIED RENIN INHIBITORS

被引：22

作者：

MAZDIYASNI, H

KONOPACKI, DB

DICKMAN, DA

ZYDOWSKY, TM

机构：

[1] ABBOTT LABS,DIV CARDIOVASC RES,PPD,D-47V,AP-10,1 ABBOTT PK RD,ABBOTT PK,IL 60064

[2] ABBOTT LABS,PROC RES CHEM,PPD,ABBOTT PK,IL 60064

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 03期

关键词：

D O I：

10.1016/0040-4039(93)85095-E

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel and efficient preparation of several racemic beta-sulfonamidopropionate esters is described. Treatment of the racemic esters with Chymotrypsin or Subtilisin Carlsberg (purified or detergent grade) provided the corresponding (S)-carboxylic acids in 60-90% yield. These acids (75 to >98 % e.e.) are useful starting materials for the synthesis of P-3 site modified renin inhibitors.

引用

收藏

页码：435 / 438

页数：4

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