LACK OF MOTHER-TO-INFANT TRANSMISSION OF HEPATITIS-C VIRUS IN HUMAN-IMMUNODEFICIENCY-VIRUS SERONEGATIVE WOMEN - A PROSPECTIVE-STUDY WITH HEPATITIS-C VIRUS-RNA TESTING

被引:122
作者
ROUDOTTHORAVAL, F
PAWLOTSKY, JM
THIERS, V
DEFORGES, L
GIROLLET, PP
GUILLOT, F
HURAUX, C
AUMONT, P
BRECHOT, C
DHUMEAUX, D
机构
[1] CHU HENRI MONDOR,DEPT HEPATOL,F-94010 CRETEIL,FRANCE
[2] CHU HENRI MONDOR,SERV BACTERIOL VIROL,F-94010 CRETEIL,FRANCE
[3] INST PASTEUR,HYBRIDOTEST,F-75724 PARIS 15,FRANCE
[4] CTR HOSP INTERCOMMUNAL,SERV PEDIAT,F-94190 VILLENEUVE ST GEO,FRANCE
[5] CTR HOSP INTERCOMMUNAL,SERV GYNECOL OBSTET,F-94000 CRETEIL,FRANCE
[6] ORTHODIAGNOST SYST,F-95700 ROISSY,FRANCE
关键词
D O I
10.1002/hep.1840170504
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The published risk of mother-to-infant transmission of hepatitis C virus varies according to the population studied and the tests used. In a prospective study we used the polymerase chain reaction to assess the risk of vertical transmission of hepatitis C virus in an unselected population of women uninfected by human immunodeficiency virus. Hepatitis C virus antibodies were sought with a second-generation enzyme-linked immunosorbent assay in 2,367 consecutive pregnant women. Forty-one were positive, and 17 consented to serological follow-up of their offspring (n = 18). A second-generation recombinant immunoblot assay, ALT determination and hepatitis C virus RNA testing were performed on maternal sera obtained during pregnancy and sera from the offspring at birth and thereafter. Five older brothers or sisters were also tested. Hepatitis C virus RNA sequences in serum were amplified with a modified nested polymerase chain reaction procedure with primers from the highly conserved 5' noncoding region of the hepatitis C virus genome. All the neonates were positive for hepatitis C virus antibodies, with enzyme-linked immunosorbent assay titers and recombinant immunoblot assay patterns similar to those of their mothers. After birth hepatitis C virus antibodies gradually disappeared within 6 mo. Hepatitis C virus RNA was consistently negative in the 18 children from birth to 24 mo (range = 3 to 24 mo) and in the 5 older children, regardless of the hepatitis C virus polymerase chain reaction status of the mothers (8 of whom were positive). In conclusion, the lack of vertical transmission of hepatitis C virus in this study suggests that unselected and human immunodeficiency virus-negative women are at low risk of perinatal transmission of hepatitis C virus, even in the presence of active hepatitis C virus replication.
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页码:772 / 777
页数:6
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