HOMOLOGY OF 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE, 8-AMINO-7-OXONONANOATE SYNTHASE, 2-AMINO-6-CAPROLACTAM RACEMASE, 2,2-DIALKYLGLYCINE DECARBOXYLASE, GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE AND ISOPENICILLIN-N-EPIMERASE WITH AMINOTRANSFERASES

Profile analysis showed the title enzymes to be homologous with the aminotransferase. 1-Aminocyclopropane-1-carboxylate synthase is closely related to subgroup 1 of aminotransferases which includes aspartate, alanine, histidinol-phosphate, tyrosine and phenylalanine aminotransferase. 2,2-Dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and 2-amino-6-caprolactam racemase are most similar to subgroup II which comprises aminotransferases with ω-amino acids as substrates. 8-Amino-7-oxononoate synthase is closely related to both subgroup I and II, and isopenicillin-N-epimerase to subgroup IV with serine and phosphoserine aminotransferase. Aminotransferases and the title enzymes belong to a regio-specific family of evolutionarily related pyridoxal-5′-phosphate-dependent enzymes. © 1994 Academic Press, Inc.