SPONTANEOUS ACETYLCHOLINE-RELEASE IN THE HIPPOCAMPUS EXHIBITS A DIURNAL-VARIATION IN BOTH YOUNG AND OLD RATS

被引：30

作者：

MIZUNO, T ^{[1
]}

ARITA, J ^{[1
]}

KIMURA, F ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV, SCH MED, DEPT PHYSIOL, KANAZAWA KU, YOKOHAMA 236, JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 02期

关键词：

ACETYLCHOLINE; HIPPOCAMPUS; DIURNAL VARIATION; AGING; MICRODIALYSIS; RAT;

D O I：

10.1016/0304-3940(94)90776-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular levels of acetylcholine (ACh) in the hippocampus were measured by the microdialysis method in freely moving young (3-4 months old) and old (18-24 months old) female rats over a period of 24 h to examine the effect of aging on hippocampal ACh release. Hippocampal ACh release during a 24-h period exhibited a diurnal variation with higher levels during the dark cycle than during the light cycle in old rats as well as young rats. The present study suggests that a diurnal variation in ACh release is maintained fairly well until the rats are at least 24 months old.

引用

页码：271 / 274

页数：4

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