TRANSCRIPTIONAL REGULATION OF RAT HEPATIC LOW-DENSITY-LIPOPROTEIN RECEPTOR AND CHOLESTEROL 7-ALPHA HYDROXYLASE BY THYROID-HORMONE

被引：82

作者：

NESS, GC ^{[1
]}

LOPEZ, D ^{[1
]}

机构：

[1] UNIV S FLORIDA,COLL MED,INST BIOMOLEC SCI,TAMPA,FL 33612

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1995年 / 323卷 / 02期

关键词：

LDL RECEPTOR; TRANSCRIPTION; WESTERN BLOTTING; THYROID HORMONE; LIVER;

D O I：

10.1006/abbi.1995.0061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Utilizing hypophysectomized and thyroidectomized rats, it is demonstrated that the rapid increase in expression of hepatic low-density lipoprotein (LDL) receptor and cholesterol 7 alpha-hydroxylase in response to thyroid hormone is due to increases in the rates of transcription of these genes. An increase in transcription of the hepatic LDL receptor gene was seen within 30 min after administration of triiodothyronine. The increase in transcription fully accounted for the increase in hepatic LDL receptor protein. Stimulation of transcription of these two genes provides for enhanced removal of LDL from serum and elimination from the body. (C) 1995 Academic Press, Inc.

引用

页码：404 / 408

页数：5

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