CHARACTERIZATION OF DBT CELL CLONES DERIVED FROM CELLS PERSISTENTLY INFECTED WITH THE JHM STRAIN OF MOUSE HEPATITIS-VIRUS

被引：8

作者：

MAEDA, A ^{[1
]}

HAYASHI, M ^{[1
]}

ISHIDA, K ^{[1
]}

MIZUTANI, T ^{[1
]}

WATANABE, T ^{[1
]}

机构：

[1] RAKUNO GAKUEN UNIV,DEPT VET RADIOL,EBETSU,HOKKAIDO 069,JAPAN

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1995年 / 57卷 / 05期

关键词：

DBT CELL; MOUSE HEPATITIS VIRUS; PERSISTENT INFECTION;

D O I：

10.1292/jvms.57.813

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Twelve clones derived from the cells persistently infected with the JHM strain (JHMV) of mouse hepatitis virus (MHV) were established from mouse asterocytoma-derived DBT cells and characterized. All the cell clones were resistant to superinfection with MHV. Only one of the persistently infected cell clone synthesized viral RNA and proteins and produced virus particles. Viral RNA was detectable in some other cell clones without production of viral protein nor the virus. No cell clones exhibited contact fusion activity. The results suggested that such variety of cell clones might have resulted from persistent infection with JHMV.

引用

页码：813 / 817

页数：5

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