This automatic system for controlling the temperature of biological materials is designed to allow the selection of cooling rates, freezing rates, storage temperatures, and warming and thawing rates. These programs are easily obtained by drawing a suitable time-temperature curve on a plastic-coated card. The control device follows the line drawn on the card and regulates the flow of the refrigerani, liquid nitrogen. This automatic control system has been used to control liquid bath temperatures, to control set point storage refrigerators, with a heat exchanger to control the temperature of a moving fluid, and to control a variable rate freezer. Biological materials have been frozen, stored, and thawed automatically. The main advantages of this automatic temperature control system are that it is easy to program, it is economical to operate, and it is versatile in its application. © 1969.