RESTORATION OF CHOLINOMIMETIC ACTIVITY BY CLONIDINE IN CHOLINERGIC PLUS NORADRENERGIC LESIONED RATS

被引：86

作者：

HAROUTUNIAN, V ^{[1
]}

KANOF, PD ^{[1
]}

TSUBOYAMA, G ^{[1
]}

DAVIS, KL ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,DEPT PSYCHIAT,NEW YORK,NY 10029

来源：

BRAIN RESEARCH | 1990年 / 507卷 / 02期

关键词：

Clonidine; Memory; Noradrenergic lesion; Nucleus basalis; Oxotremorine; Physostigmine;

D O I：

10.1016/0006-8993(90)90280-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of combined lesions of forebrain cholinergic and noradrenergic systems on memory and responsitivity to the memory enhancing effects of cholinomimetics were investigated in rats. Forebrain noradrenergic deficits produced by the injection of 6-hydroxydopamine into the ascending noradrenergic bundle (ANB) blocked the ability of cholinomimetics such as physostigmine and oxotremorine to enhance retention test performance in nucleus basalis of Meynert lesioned rats. Low doses of the noradrenergic receptor agonist clonidine, when administered in conjunction with cholinomimetics reversed this blockade. These results suggest that combined cholinergic/noradrenergic therapy may be of value in the treatment of some Alzheimer's disease patients. © 1990.

引用

页码：261 / 266

页数：6

共 40 条

[1] CHANGES IN THE BRAIN CATECHOLAMINES IN PATIENTS WITH DEMENTIA OF ALZHEIMER TYPE [J].

ADOLFSSON, R ;

GOTTFRIES, CG ;

ROOS, BE ;

WINBLAD, B .

BRITISH JOURNAL OF PSYCHIATRY, 1979, 135 (SEP) :216-223

[2]

ARAI H, 1984, J NEUROCHEM, V43, P388

[3]

ARNSTEN AFT, 1988, J NEUROSCI, V8, P4287

[4] CATECHOLAMINES AND COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES [J].

ARNSTEN, AFT ;

GOLDMANRAKIC, PS .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 444 (MAY) :218-234

[5] ALPHA-2-ADRENERGIC MECHANISMS IN PREFRONTAL CORTEX ASSOCIATED WITH COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES [J].

ARNSTEN, AFT ;

GOLDMANRAKIC, PS .

SCIENCE, 1985, 230 (4731) :1273-1276

[6] LOSS OF NEURONS OF ORIGIN OF THE ADRENERGIC PROJECTION TO CEREBRAL-CORTEX (NUCLEUS LOCUS CERULEUS) IN SENILE DEMENTIA [J].

BONDAREFF, W ;

MOUNTJOY, CQ ;

ROTH, M .

NEUROLOGY, 1982, 32 (02) :164-168

[7]

CROSS AJ, 1987, NEURONAL SEROTONIN, P231

[8] REDUCED SOMATOSTATIN-LIKE IMMUNOREACTIVITY IN CEREBRAL-CORTEX FROM CASES OF ALZHEIMER-DISEASE AND ALZHEIMER SENILE DEMENTIA [J].

DAVIES, P ;

KATZMAN, R ;

TERRY, RD .

NATURE, 1980, 288 (5788) :279-280

[9] CORTICAL SOMATOSTATIN-LIKE IMMUNOREACTIVITY IN CASES OF ALZHEIMERS-DISEASE AND SENILE DEMENTIA OF THE ALZHEIMER TYPE [J].

DAVIES, P ;

TERRY, RD .

NEUROBIOLOGY OF AGING, 1981, 2 (01) :9-14

[10]

DAVIES P, 1976, LANCET, V2, P1403

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