COMPARISON OF THE ANTIBODIES ELICITED BY THE INDIVIDUAL STRUCTURAL POLYPEPTIDES OF FOOT-AND-MOUTH-DISEASE AND POLIO VIRUSES

Antibody produced against preparations of VP1, one of the four structural polypeptides of foot-and-mouth disease virus, neutralized the virus and reacted with both full and empty particles in radioimmunoassay (RIA) Antiserum against VP2 reacted with artifical empty particles of the virus but not with full particles. In contrast, none of the individual polypeptides of poliovirus produced antisera which neutralized the virus nor reacted with it in RIA. However, antisera produced with VP1 and VP2 reacted with artificial empty particles in RIA.