CONTROL OF REMOTE ENOATE GEOMETRY IN THE BRYOSTATINS WITH A TETHERED HORNER-WADSWORTH-EMMONS REAGENT

被引：51

作者：

EVANS, DA

CARREIRA, EM

机构：

[1] Department of Chemistry, Harvard University Cambridge

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(00)97711-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereochemistry of the exocyclic unsaturated ester at C13 of the bryostatins may be established with a tethered phosphonate reagent anchored to a proximal hydroxyl function at C16 of an advanced intermediate en route to the total syntheses of the bryostatins. © 1990.

引用

页码：4703 / 4706

页数：4

共 9 条

[1] DIRECTED REDUCTION OF BETA-HYDROXY KETONES EMPLOYING TETRAMETHYLAMMONIUM TRIACETOXYBOROHYDRIDE
EVANS, DA
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (11) : 3560 - 3578
[2] SYNTHESIS OF OPTICALLY-ACTIVE 3-OXA-CARBACYCLIN PRECURSORS FEATURING ASYMMETRIC HORNER-EMMONS REACTION
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[J]. TETRAHEDRON LETTERS, 1988, 29 (15) : 1773 - 1774
[3] THE STEREOSELECTIVE SYNTHESIS OF ACYCLIC AND EXOCYCLIC TRISUBSTITUTED OLEFINS VIA A HYDROXYL-DIRECTED WITTIG REACTION
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[4] DESIGN AND REACTIVITY OF TOPOLOGICALLY UNIQUE, CHIRAL PHOSPHONAMIDES - REMARKABLE DIASTEREOFACIAL SELECTIVITY IN ASYMMETRIC OLEFINATION AND ALKYLATION
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[5] LITHIUM "TRIS[(3-ETHYL-3-PENTYL)OXY]ALUMINUM HYDRIDE - A NEW REMARKABLY CHEMOSELECTIVE REAGENT FOR THE REDUCTION OF ALDEHYDES IN THE PRESENCE OF KETONES
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[J]. JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (22) : 4628 - 4629
[6] ANTINEOPLASTIC AGENTS .126. ISOLATION AND STRUCTURE OF BRYOSTATIN-12 AND BRYOSTATIN-13
PETTIT, GR
LEET, JE
HERALD, CL
KAMANO, Y
BOETTNER, FE
BACZYNSKYJ, L
NIEMAN, RA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (13) : 2854 - 2860
[7] ANTI-NEOPLASTIC AGENTS .86. ISOLATION AND STRUCTURE OF BRYOSTATIN-1
PETTIT, GR
HERALD, CL
DOUBEK, DL
HERALD, DL
ARNOLD, E
CLARDY, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (24) : 6846 - 6848
[8] E-SELECTIVE OR Z-SELECTIVE HORNER-WITTIG REACTIONS OF SUBSTITUTED BICYCLO[3.3.0]OCTANE-3-ONES WITH CHIRAL PHOSPHONOACETATES
REHWINKEL, H
SKUPSCH, J
VORBRUGGEN, H
[J]. TETRAHEDRON LETTERS, 1988, 29 (15) : 1775 - 1776
[9] ACIDITY OF (Z)-METHYL AND (E)-METHYL ACETATES - RELATIONSHIP TO MELDRUM ACID
WIBERG, KB
LAIDIG, KE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (06) : 1872 - 1874

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