KONBAMIDE, A NOVEL PEPTIDE WITH CALMODULIN ANTAGONISTIC ACTIVITY FROM THE OKINAWAN MARINE SPONGE THEONELLA SP

被引：63

作者：

KOBAYASHI, J

SATO, M

MURAYAMA, T

ISHIBASHI, M

WALCHI, MR

KANAI, M

SHOJI, J

OHIZUMI, Y

机构：

[1] SHOWA UNIV,FAC PHARMACEUT SCI,SHINAGAWA KU,TOKYO 142,JAPAN

[2] BROKER JAPAN CO,TSUKUBA,IBARAKI 305,JAPAN

[3] FINNIGAN MAT INSTRUMENTS CO,CHIYODA KU,TOKYO 102,JAPAN

[4] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 15期

关键词：

D O I：

10.1039/c39910001050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel peptide, konbamide 1, with calmodulin antagonistic activity has been isolated from the Okinawan marine sponge Theonella sp. and the structure elucidated to be a unique hexapeptide with an ureido bond on the basis of spectroscopic data, including two-dimensional NMR techniques and FAB MS-MS analysis (FAB = fast atom bombardment).

引用

页码：1050 / 1052

页数：3

共 21 条

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