LORACARBEF CONCENTRATIONS IN MIDDLE-EAR FLUID

被引：22

作者：

KUSMIESZ, H

SHELTON, S

BROWN, O

MANNING, S

NELSON, JD

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT OTORHINOLARYNGOL,DALLAS,TX 75235

[2] UNIV TEXAS,SW MED CTR,DEPT PEDIAT,DALLAS,TX 75235

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 10期

关键词：

D O I：

10.1128/AAC.34.10.2030

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean ± standard deviation concentrations in MEF were 2.0 ± 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 ± 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.

引用

页码：2030 / 2031

页数：2

共 4 条

[1] PENETRATION OF AMOXICILLIN, CEFACLOR, ERYTHROMYCIN-SULFISOXAZOLE, AND TRIMETHOPRIM-SULFAMETHOXAZOLE INTO THE MIDDLE-EAR FLUID OF PATIENTS WITH CHRONIC SEROUS OTITIS-MEDIA [J].