NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF THE CANINE ADENOVIRUS TYPE-1 PROTEINASE

被引：3

作者：

CAI, FX ^{[1
]}

WEBER, JM ^{[1
]}

机构：

[1] UNIV SHERBROOKE,FAC MED,DEPT MICROBIOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

VIRUS GENES | 1992年 / 6卷 / 03期

关键词：

CANINE ADENOVIRUS TYPE-1; PROTEINASE;

D O I：

10.1007/BF01702569

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The DNA sequence of an open reading frame (ORF) corresponding to the canine adenovirus type 1 (Can1) proteinase gene was determined. A total of 1171 base pairs were sequenced from the downstream end of the HindIII-A Can1 genomic fragment, including adjacent regions corresponding to the carboxy-terminal portions of the hexon and the DNA-binding proteins. The predicted Can1 proteinase consists of 206 residues (23,325 D) of which 68% are identical and 83% are similar to the sequence of the human Ad2 proteinase. Alignment with the Ad2 proteinase identified a number of conserved residues that could form part of the catalytic triad of the enzyme.

引用

页码：307 / 312

页数：6

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