YACS, BACS, PACS AND MACS - ARTIFICIAL CHROMOSOMES AS RESEARCH TOOLS

被引：106

作者：

MONACO, AP ^{[1
]}

LARIN, Z ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT BIOCHEM,CRC,CHROMOSOME MOLEC BIOL GRP,OXFORD OX1 3QU,ENGLAND

来源：

TRENDS IN BIOTECHNOLOGY | 1994年 / 12卷 / 07期

关键词：

D O I：

10.1016/0167-7799(94)90140-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Yeast artificial chromosomes (YACs) have become essential research tools as they enable large fragments of DNA to be cloned. In order to overcome several disadvantages of YACs, including chimaerism and instability, several complementary bacterial artificial chromosome (BAC) vectors have been developed. More recently, attempts are being made to construct artificial chromosomes in mammalian cells (MACs).

引用

页码：280 / 286

页数：7

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