HYPERACTIVITY IN THE OFFSPRING OF NICOTINE-TREATED RATS - ROLE OF THE MESOLIMBIC AND NIGROSTRIATAL DOPAMINERGIC PATHWAYS

被引:83
作者
RICHARDSON, SA [1 ]
TIZABI, Y [1 ]
机构
[1] HOWARD UNIV,COLL MED,DEPT PHARMACOL,WASHINGTON,DC 20059
关键词
NICOTINE; HYPERACTIVITY; DOPAMINE; D-2; RECEPTOR; MESOLIMBIC; NIGROSTRIATAL;
D O I
10.1016/0091-3057(94)90018-3
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
To evaluate the involvement of the mesolimbic and nigrostriatal dopaminergic systems in hyperactivity in offspring of nicotine-treated dams, timed-pregnant Sprague-Dawley rats were implanted SC on gestational day 4 with osmotic minipumps to receive saline or nicotine (3 or 6 mg/kg/day) for 16 days. Hyperactive and nonhyperactive male offspring of nicotine-treated dams as well as nonhyperactive offspring of saline-treated darns were selected and sacrificed at day 22 postnatally. Discrete brain areas (the nucleus accumbens [NAcc], striatum [STR], frontal cortex [FC], ventral tegmental area [VTA], and substantia nigra [SN]) were microdissected for the evaluation of dopamine (DA) concentration and/or the D-2 receptor subtype. Dopamine concentration was decreased in the VTA and STR but was increased in the SN of the hyperactive offspring. The reduction in striatal DA level was associated with a reduction in the number of D-2 receptors in that area. The data suggest a role for the VTA and striatal dopaminergic system in offspring hyperactivity.
引用
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页码:331 / 337
页数:7
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