THE PREPARATION AND CHARACTERIZATION OF SOME AMINESULFOXIDEDICHLOROPLATINUM(II) COMPLEXES

A series of compounds designed to bind to GpA sequences of DNA has been prepared and characterised. Procedures have been developed for the syntheses of [Pt{MeS(O)CH2CH2NH2}Cl2] 1 and (2S,SR)- and (2S,SS)-[Pt{MeS(O)CH2CH2CH(CO2Me)NH2}Cl2] 2a, 2b. The crystal structures of 1 and of the two diastereomers, 2a and 2b, have been determined. Crystals of 1 are orthorhombic, space group Pcab, a = 9.405(l), b = 10.847(l), c = 16.170(l) angstrom, Z = 8, R 0.30 for 1410 reflections. Crystals of 2a are orthorhombic, space group P2(1)2(1)2(1), a = 9.738(l), b 10.588(l), c = 11.090(1) angstrom, Z = 4, R = 0.021 for 1382 reflections. Crystals of 2b are orthorhombic, space group P2(1)2(1)2(1), a = 10.977(3), b = 13.738(9), c = 25.24(1) angstrom, Z = 12, R = 0.078 for 1482 reflections. Energy minimisation calculations have been used to develop a force field for a series of dichloroplatinum(ii) sulfoxide complexes.