TRISNORSQUALENE METHYL HYDROXYLAMINE - A POTENT DUAL INHIBITOR OF MAMMALIAN SQUALENE EPOXIDASE AND OXIDOSQUALENE CYCLASE

被引：5

作者：

ANSTEAD, GM ^{[1
]}

LIN, HK ^{[1
]}

PRESTWICH, GD ^{[1
]}

机构：

[1] SUNY,DEPT CHEM,STONY BROOK,NY 11794

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80339-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes in the sterol biosynthesis pathway, are inhibited effectively by trisnorsqualene methyl hydroxylamine.

引用

页码：1319 / 1322

页数：4

共 22 条

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