DECREASED IN-VITRO MEGAKARYOCYTE COLONY FORMATION IN CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA

被引：16

作者：

ABGRALL, JF

BERTHOU, C

SENSEBE, L

LENIGER, C

ESCOFFRE, M

机构：

[1] Department of Haematology, University of Brest, School of Medicine, Brest

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1993年 / 85卷 / 04期

关键词：

D O I：

10.1111/j.1365-2141.1993.tb03227.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vitro megakaryocyte colony formation was studied in 25 patients with chronic idiopathic thrombocytopenic purpura (ITP), and compared to 16 controls. A significantly lower number of megakaryocyte progenitors (CFU-MK) was observed in patients (10.8 +/- 12.0 CFU-MK per 10(5) bone-marrow non-adherent mononuclear cells (NAMC). compared to controls (22.5 +/- 15.4 CFU-MK); P<0.002. Only six patients had a normal number of CFU-MK. The number of CFU-MK was not correlated to initial platelet count (P = 0.35). These findings indicate that in vitro CFU-MK could be of interest in the diagnosis of chronic ITP, and also could be predictive for chronicity in patients with acute ITP.

引用

页码：803 / 804

页数：2

共 5 条

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[4]

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[5]

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