ASPERFURAN, A NOVEL ANTIFUNGAL METABOLITE FROM ASPERGILLUS-ORYZAE

被引：38

作者：

PFEFFERLE, W ^{[1
]}

ANKE, H ^{[1
]}

BROSS, M ^{[1
]}

STEFFAN, B ^{[1
]}

VIANDEN, R ^{[1
]}

STEGLICH, W ^{[1
]}

机构：

[1] UNIV BONN,DEPT ORGAN CHEM & BIOCHEM,W-5300 BONN,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 06期

关键词：

D O I：

10.7164/antibiotics.43.648

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphological changes in Mucor miehei at very low concentrations (20 ng/disc) while growth was only partly inhibited. In HeLa S3 and L1210 cells it showed weak cytotoxicity, the IC50 was 25 μg/ml. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：648 / 654

页数：7

共 20 条

[1] METABOLIC PRODUCTS OF MICROORGANISMS .206. DEFLECTINS, NEW ANTI-MICROBIAL AZAPHILONES FROM ASPERGILLUS-DEFLECTUS [J].

ANKE, H ;

KEMMER, T ;

HOFLE, G .

JOURNAL OF ANTIBIOTICS, 1981, 34 (08) :923-928

[2] STRUCTURE-ACTIVITY-RELATIONSHIPS FOR UNSATURATED DIALDEHYDES .3. MUTAGENIC, ANTIMICROBIAL, CYTO-TOXIC, AND PHYTOTOXIC ACTIVITIES OF MERULIDIAL DERIVATIVES [J].

ANKE, H ;

STERNER, O ;

STEGLICH, W .

JOURNAL OF ANTIBIOTICS, 1989, 42 (05) :738-744

[3] STROBILURINS - NEW ANTIFUNGAL ANTIBIOTICS FROM BASIDIOMYCETE STROBILURUS-TENACELLUS (PERS EX FR) SING [J].

ANKE, T ;

OBERWINKLER, F ;

STEGLICH, W ;

SCHRAMM, G .

JOURNAL OF ANTIBIOTICS, 1977, 30 (10) :806-810

[4] MODIFICATION OF THE NICKEL REACTION - A GENERAL SYNTHETIC APPROACH TO 2-VINYL-2,3-DIHYDROBENZOFURANS [J].

BIGI, F ;

CASIRAGHI, G ;

CASNATI, G ;

SARTORI, G .

TETRAHEDRON, 1983, 39 (01) :169-174

[5] ABSOLUTE CONFIGURATIONS OF TREMETONE + TOXOL [J].

BONNER, WA ;

BURKE, NI ;

FLECK, WE ;

ZALKOW, JH ;

SJOBERG, B ;

JOULE, JA ;

HILL, RK .

TETRAHEDRON, 1964, 20 (06) :1419-&

[6] NEW BENZOFURANS FROM STEREUM-SUBPILEATUM, THEIR BIOSYNTHESIS, AND RELATED PROCESSES OF AROMATIC AMINOACID METABOLISM IN A BASIDIOMYCETE [J].

BULOCK, JD ;

KAYE, B ;

HUDSON, AT .

PHYTOCHEMISTRY, 1971, 10 (05) :1037-&

[7]

CLARK JM, 1964, EXPT BIOCH, P166

[8] DIHYDROBENZOFURANS FROM HETEROBASIDION-ANNOSUM [J].

DONNELLY, DMX ;

FUKUDA, N ;

KOUNO, I ;

MARTIN, M ;

OREILLY, J .

PHYTOCHEMISTRY, 1988, 27 (08) :2709-2713

[9] SCREENING OF ANTI-FUNGAL ANTIBIOTICS ACCORDING TO ACTIVITIES INDUCING MORPHOLOGICAL ABNORMALITIES [J].

GUNJI, S ;

ARIMA, K ;

BEPPU, T .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1983, 47 (09) :2061-2069

[10] LEPTOMYCIN-A AND LEPTOMYCIN-B, NEW ANTIFUNGAL ANTIBIOTICS .3. MODE OF ACTION OF LEPTOMYCIN-B ON SCHIZOSACCHAROMYCES-POMBE [J].

HAMAMOTO, T ;

UOZUMI, T ;

BEPPU, T .

JOURNAL OF ANTIBIOTICS, 1985, 38 (11) :1573-1580

← 1 2 →