SYNTHESIS OF L-2-(2,3-DICARBOXYCYCLOPROPYL)GLYCINES - NOVEL CONFORMATIONALLY RESTRICTED GLUTAMATE ANALOGS

被引：81

作者：

OHFUNE, Y ^{[1
]}

SHIMAMOTO, K ^{[1
]}

ISHIDA, M ^{[1
]}

SHINOZAKI, H ^{[1
]}

机构：

[1] TOKYO METROPOLITAN INST MED SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80083-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New conformationally restricted glutamate agonists 1 and 2 possessing both an extended and a folded conformation of L-glutamate in their structures have been efficiently synthesized in a stereoselective manner. The synthesis of 1 involved a novel alpha-carbomethoxycyclopropyl anion equilibration.

引用

页码：15 / 18

页数：4

共 17 条

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