SOME FACTORS AFFECTING THE INVITRO PENETRATION OF IBUPROFEN THROUGH HUMAN SKIN

被引：26

作者：

BIALIK, W

WALTERS, KA

BRAIN, KR

HADGRAFT, J

机构：

[1] AN EX,REDWOOD BLDG,KING EDWARD VII AVE,CARDIFF CF1 3XF,WALES

[2] UWCC,WELSH SCH PHARM,CARDIFF CF1 3XF,WALES

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 92卷 / 1-3期

关键词：

IBUPROFEN; SKIN PENETRATION; INVITRO; HUMAN SKIN; TRANSCUTOL; POLYOXYETHYLENE ALKYL ETHER; NONIONIC SURFACTANT; FORMULATION;

D O I：

10.1016/0378-5173(93)90283-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of various factors on the permeation of ibuprofen across human skin in vitro was determined. Permeation was increased by increasing the volume fraction of water in binary water-transcutol solvent mixtures, probably due to changes in thermodynamic activity. Permeation was also increased in the presence of nonionic surfactants based on an oleyl alkyl chain although this effect was saturable. The data confirmed that it is possible to develop improved formulation strategies to optimise the delivery of ibuprofen across the skin,

引用

页码：219 / 223

页数：5

共 9 条

[1]

Bialik W, 1991, PREDICTION PERCUTANE, V2, P458

[2] METHODS FOR INVITRO PERCUTANEOUS-ABSORPTION STUDIES .6. PREPARATION OF THE BARRIER LAYER [J].