RESOLUTION ENHANCED NMR-SPECTROSCOPY IN BIOLOGICAL-SYSTEMS VIA MAGNETIC-SUSCEPTIBILITY MATCHED SAMPLE IMMERSION CHAMBERS

被引：26

作者：

BALLON, D

MAHMOOD, U

JAKUBOWSKI, A

KOUTCHER, JA

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT MED PHYS,NEW YORK,NY 10021

[2] MEM SLOAN KETTERING CANC CTR,DEPT RADIOL,NEW YORK,NY

[3] MEM SLOAN KETTERING CANC CTR,DEPT MED,NEW YORK,NY 10021

来源：

MAGNETIC RESONANCE IN MEDICINE | 1993年 / 30卷 / 06期

关键词：

IN VIVO; SPECTROSCOPY; SUSCEPTIBILITY; IMMERSION;

D O I：

10.1002/mrm.1910300615

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A technique is described which reduced the magnetic susceptibility induced line broadening in NMR spectra obtained from three biological systems at 4.7 Tesla. Proton spectra from a sealed suspension of HL60 leukemic myeloblasts yielded minimum linewidths of 1.3 Hz at 200 MHz(0.0065 ppm) after 10 min of automated shimming. P-31 spectra from an in vivo murine MCa mammary carcinoma yielded a well-resolved phosphorylcholine resonance without proton decoupling and with the resistive shim coll currents set to zero. P-31 spectra from a perfused suspension of RIF-1 fibrosarcoma cells exhibited a gamma-nucleoside triphosphate resonance which was resolved into purine and pyrimidine components.

引用

页码：754 / 758

页数：5

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