INHIBITION OF KAINIC ACID-BINDING TO GLUTAMATE RECEPTORS BY EXTRACTS OF GASTRODIA

被引：32

作者：

ANDERSSON, M

BERGENDORFF, O

NIELSEN, M

STERNER, O

WITT, R

AI, JL

LU, AP

WANG, AM

机构：

[1] SCT HANS MENTAL HOSP,DEPT BIOCHEM,DK-4000 ROSKILDE,DENMARK

[2] LUND UNIV,DIV ORGAN CHEM 2,S-22100 LUND,SWEDEN

[3] CHINESE ACAD TRADIT CHINESE MED,INST BASIC THEORY,BEIJING 100700,PEOPLES R CHINA

来源：

PHYTOCHEMISTRY | 1995年 / 38卷 / 04期

关键词：

GASTRODIA ELATA; ORCHIDACEAE; KAINIC ACID; GLUTAMATE RECEPTOR; GLUTATHIONE DERIVATIVE;

D O I：

10.1016/0031-9422(94)00771-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.

引用

页码：835 / 836

页数：2

共 8 条

[1] CALCIUM DISCRIMINATES 2 [H-3] KAINATE BINDING-SITES WITH DIFFERENT MOLECULAR TARGET SIZES IN RAT CORTEX [J].