CHANGES OF BLOOD-VISCOSITY IN PATIENTS TREATED WITH 5-FLUOROURACIL - A LINK TO CARDIOTOXICITY

被引：23

作者：

CWIKIEL, M

PERSSON, SU

LARSSON, H

ALBERTSSON, M

ESKILSSON, J

机构：

[1] UNIV LUND HOSP,DEPT CARDIOL,S-22185 LUND,SWEDEN

[2] UNIV LUND HOSP,DEPT INTERNAL MED,S-22185 LUND,SWEDEN

来源：

ACTA ONCOLOGICA | 1995年 / 34卷 / 01期

关键词：

D O I：

10.3109/02841869509093643

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU. The study showed a decrease in blood and plasma viscosity during treatment,vith 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients.

引用

页码：83 / 85

页数：3

共 24 条

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