A DEVELOPMENTALLY-REGULATED CHROMOSOMAL ORIGIN OF REPLICATION USES ESSENTIAL TRANSCRIPTION ELEMENTS

被引：65

作者：

MARCZYNSKI, GT ^{[1
]}

LENTINE, K ^{[1
]}

SHAPIRO, L ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,BECKMAN CTR,DEPT DEV BIOL,STANFORD,CA 94305

来源：

GENES & DEVELOPMENT | 1995年 / 9卷 / 12期

关键词：

CAULOBACTER; ORIGIN OF REPLICATION; TRANSCRIPTION; POLAR DEVELOPMENT; HEME;

D O I：

10.1101/gad.9.12.1543

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Only one of the two chromosomes in the asymmetric Caulobacter predivisional cell initiates replication in the progeny cells. Transcription from a strong promoter within the origin occurs uniquely from the replication-competent chromosome at the stalked pole of the predivisional cell. This regulated promoter has an unusual sequence organization, and transcription from this promoter is essential for regulated (cell type-specific) replication. Our analysis defines a new class of bacterial origins and suggests a coupling between transcription and replication that is consistent with the phylogenetic relationship of Caulobacter to the ancestral mitochondrion.

引用

页码：1543 / 1557

页数：15

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