PROTECTING GROUPS FOR NUCLEOSIDES USED IN SYNTHESIZING OLIGONUCLEOTIDES

被引：55

作者：

LETSINGER, RL

MILLER, PS

机构：

[1] Department of Chemistry, Northwestern University, Evanston

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1969年 / 91卷 / 12期

关键词：

D O I：

10.1021/ja01040a043

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three protecting groups useful in syntheses involving nucleosides are described. These are β-benzoyl propionyl and benzoylformyl for OH groups of nucleosides and isobutyloxycarbonyl for NH2 of the cytosine ring. The preparation and properties of 3ʹ-O- and 5ʹ-O-(β-benzoylpropionyl)thymidine, 3ʹ-O-benzoylformylthymi-dine, and N5-isobutyloxycarbonyl-3ʹ-O-β-benzoylpropionyl)deoxycytidine are described. © 1969, American Chemical Society. All rights reserved.

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页码：3356 / +

页数：1

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