METABOLIC FATE OF ORALLY ADMINISTERED QUINIDINE GLUCONATE IN HUMANS

被引：47

作者：

PALMER, KH

MARTIN, B

BAGGETT, B

WALL, ME

机构：

[1] Chemistry and Life Sciences Laboratory, Research Triangle Institute, Research Triangle Park

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 08期

关键词：

D O I：

10.1016/0006-2952(69)90280-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oral administration of quinidine (I) preparations to humans has been shown by mass spectroscopy(ms),gas-liquid chromatography/ms(GLC/ms)and other analytical techniques to give a wide range of urinary metabolites. These are found as the free, or to a minor extent, as the β-glucosiduronate conjugates. The major metabolites isolated and characterized represent two oxidative modifications of (I), and of 2'-quinolone and hydroxyquinuclidine derivatives. Also found were polyoxygenated quinidine derivatives. Current supplies of quinidine were found consistently to contain 10 to 30 per cent of an impurity. © 1969.

引用

页码：1845 / &

共 13 条

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