PROSTAGLANDINS-V .1. SYNTHESIS AND PHARMACOLOGY OF (+/-)-11-DEOXY-10-HYDROXYPROSTAGLANDIN-E1 METHYL-ESTER

被引：4

作者：

CATON, MPL

DARNBROUGH, G

HAMBLING, DJ

JORDAN, R

PARKER, T

机构：

[1] The Research Laboratories, May and Baker Ltd., Dagenham

来源：

PROSTAGLANDINS | 1979年 / 18卷 / 04期

关键词：

D O I：

10.1016/0090-6980(79)90024-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(±)-11-Deoxy-10-hydroxy-PGE1 methyl ester (Va) has been synthesised via conjugate addition of the cuprate (III) to the 5-tetrahydropyranyloxycyclopentenone (IId). Va was found to be 0.1 times as active as PGE1 as a uterine stimulant in the anaesthetized pregnant rat, 0.25 times as active as PGE1 in causing vasodepression in the anaesthetized cat, and approximately equiactive to PGE1 in inducing bronchoconstriction. © 1979.

引用

页码：569 / 576

页数：8

共 6 条

[1] PROSTAGLANDINS .4. SYNTHESIS OF (+/-)-11-DEOXYPROSTAGLANDINS FROM 2-(OMEGA-HYDROXYHEPTYL)CYCLOPENT-2-ENONES [J].