CORTICOTROPIN-RELEASING FACTOR ANTAGONIST BLOCKS MICROWAVE-INDUCED DECREASES IN HIGH-AFFINITY CHOLINE UPTAKE IN THE RAT-BRAIN

被引：19

作者：

LAI, H

CARINO, MA

HORITA, A

GUY, AW

机构：

[1] UNIV WASHINGTON, SCH MED, DEPT BEHAV SCI, SEATTLE, WA 98195 USA

[2] UNIV WASHINGTON, SCH MED, DEPT PSYCHIAT, SEATTLE, WA 98195 USA

[3] UNIV WASHINGTON, SCH MED, DEPT BIOENGN, SEATTLE, WA 98195 USA

来源：

BRAIN RESEARCH BULLETIN | 1990年 / 25卷 / 04期

关键词：

Corticotropin-releasing factor; Frontal cortex; Hippocampus; Low-level microwaves; Sodium-dependent high-affinity choline uptake;

D O I：

10.1016/0361-9230(90)90120-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acute (45-min) irradiation with pulsed low-level microwaves (2450-MHz, 2 μsec pulses at 500 pps, average power density of 1 mW/cm2, whole-body average specific absorption rate of 0.6 W/kg) decreased sodium-dependent high-affinity choline uptake (HACU) activity in the frontal cortex and hippocampus of the rat. These effects were blocked by pretreating the animals before exposure with intracerebroventricular injection of the specific corticotropin-releasing factor (CRF) receptor antagonist, α-helical-CRF9-41 (25 μg). Similar injection of the antagonist had no significant effect on HACU in the brain of the sham-exposed rats. These data suggest that low-level microwave irradiation activates CRF in the brain, which in turn causes the changes in central HACU. © 1990.

引用

页码：609 / 612

页数：4

共 21 条

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