ACETYLENIC AND ALLENIC DERIVATIVES OF 2-(5-BENZYLOXYINDOLYL) AND 2-(5-HYDROXYINDOLYL)METHYLAMINES - SYNTHESIS AND INVITRO EVALUATION AS MONOAMINE-OXIDASE INHIBITORS

被引:33
作者
CRUCES, MA [1 ]
ELORRIAGA, C [1 ]
FERNANDEZALVAREZ, E [1 ]
机构
[1] CSIC,INST QUIM ORGAN GEN,JUAN CIERVA 3,E-28006 MADRID,SPAIN
关键词
ACETYLENIC AND ALLENIC 2-INDOLYLMETHYLAMINE DERIVATIVES; MONOAMINE OXIDASE INHIBITORS;
D O I
10.1016/0223-5234(91)90210-E
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
We report the synthesis and in vitro studies as MAO inhibitors of 2 series of new acetylenic and allenic derivatives of 2-(5-benzyloxyindolyl)- and 2-(5-hydroxyindolyl)methylamines and their indolylmethylamine precursors. All compounds were MAO inhibitors and either did not show selectivity (the benzyloxy compounds 5) or were selective for MAO-A (most of the hydroxy compounds 7). Three of the studied compounds, 7d, 7g and 7i, were found to be slightly more selective for MAO-A than clorgyline.
引用
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页码:33 / 41
页数:9
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