STRUCTURE OF POLYVINYLPYRROLIDONE-IODINE (POVIDONE-IODINE)

被引：73

作者：

SCHENCK, HU

SIMAK, P

HAEDICKE, E

机构：

[1] Plastics Laboratory, BASF Aktiengesellschaft, Ludwigshafen

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 12期

关键词：

Anti‐infectives; topical—povidone‐iodine; structure; hydrogen triiodide adducts; ‐ IR spectra; X‐ray structure analysis; Models; molecular—povidone‐iodine; Povidone‐iodine—structure; IR spectra;

D O I：

10.1002/jps.2600681211

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hydrogen triiodide adducts were prepared from N,N‐dimethylacetamide, N‐alkylpyrrolidone derivatives, and polyvinylpyrrolidone, and their structures were investigated by IR spectra and X‐ray structure analyses and compared with the structure of povidone‐iodine USP. The results suggest that the iodine in povidone‐iodine USP is complexed by the polymer such that a proton is fixed via a short hydrogen bond between two carbonyl groups of two pyrrolidone rings and that a triiodide anion is bound ionically to this cation. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1505 / 1509

页数：5

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