DYSTROPHIN-LIKE IMMUNOREACTIVITY IN MONKEY AND HUMAN BRAIN-AREAS INVOLVED IN LEARNING AND MOTOR FUNCTIONS

被引：28

作者：

HUARD, J ^{[1
]}

COTE, PY ^{[1
]}

PARENT, A ^{[1
]}

BOUCHARD, JP ^{[1
]}

TREMBLAY, JP ^{[1
]}

机构：

[1] UNIV LAVAL,HOP ENFANT JESUS,NEUROBIOL LAB,1401 18E RUE,LAVAL G1J 1Z4,QUEBEC,CANADA

来源：

NEUROSCIENCE LETTERS | 1992年 / 141卷 / 02期

基金：

英国医学研究理事会;

关键词：

DYSTROPHIN; DYSTROPHIN-LIKE PROTEIN; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; IMMUNOBLOTTING; HUMAN; MONKEY;

D O I：

10.1016/0304-3940(92)90890-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two antidystrophin antibodies against different fragments of dystrophin were used to detect this polypeptide in monkey and human brains. Dystrophin was revealed by immunoperoxidase amplified with the biotin/avidin system and by immunoblotting. A dystrophin-like immunoreactivity was uniformly expressed in several brain regions implicated in learning and motor functions. Dystrophin function is not clear but our results raise the possibility that this protein may be involved in the cognitive impairment observed in several Duchenne muscular dystrophy (DMD) patients.

引用

页码：181 / 186

页数：6

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