HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION OF HUMAN BRAIN CAPILLARY ENDOTHELIAL-CELLS OCCURS VIA A CD4 GALACTOSYLCERAMIDE-INDEPENDENT MECHANISM

被引:202
作者
MOSES, AV
BLOOM, FE
PAUZA, CD
NELSON, JA
机构
[1] OREGON HLTH SCI UNIV, DEPT MICROBIOL & IMMUNOL, L220, 3181 SW SAM JACKSON PK RD, PORTLAND, OR 97201 USA
[2] Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA
[3] UNIV WISCONSIN, DEPT PATHOL & LAB MED, MADISON, WI 53706 USA
关键词
AIDS; NEUROLOGIC DISEASE; BLOOD-BRAIN BARRIER;
D O I
10.1073/pnas.90.22.10474
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neuropathologic studies of AIDS patients have shown that brain capillary endothelial cells are a cellular target for human immunodeficiency virus (HIV) in vivo. We have established in vitro cultures of primary human brain capillary endothelial (HBCE) cells. Using this model system, we have shown a significant HIV infection of HBCE cells that is productive yet noncytopathic. The infection is mediated by a cellular interaction with gp120 that does not involve CD4 or galactosylceramide. HIV infection of HBCE cells may contribute to AIDS-associated neuropathology by disturbing the physiology of the endothelium and directly or indirectly facilitating dissemination of virus to the central nervous system.
引用
收藏
页码:10474 / 10478
页数:5
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