MOTILIN RECEPTOR - A MODEL FOR DEVELOPMENT OF PROKINETICS

被引：16

作者：

PEETERS, TL

DEPOORTERE, I

机构：

[1] From the Gut Hormone Lab, Department of Medical Research, University of Leuven, Leuven

来源：

DIGESTIVE DISEASES AND SCIENCES | 1994年 / 39卷 / 12期

关键词：

MOTILIN; ERYTHROMYCIN; MOTILIDE; MOTILINOMIMETIC; MIGRATING MOTOR COMPLEX;

D O I：

10.1007/BF02300377

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Erythromycin and related macrolides act as smooth muscle and neural receptors to contract rabbit duodenum and induce phase III migrating motor complex (MMC) activity in intact dogs. A recently developed motilin antagonist confirms that motility effects of erythromycin are mediated by motilin receptors. Despite species, organ, and tissue heterogeneity of motilin receptors, binding experiments with rodent antral smooth muscle tissue provide a good model for the development of this new class of prokinetics.

引用

页码：S76 / S78

页数：3

共 5 条

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[4]

PEETERS TL, 1993, GASTROINTEST MOTIL, V5, P210

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