TRANSTUBULAR POTASSIUM CONCENTRATION GRADIENT - A USEFUL TEST TO ESTIMATE RENAL ALDOSTERONE BIOACTIVITY IN INFANTS AND CHILDREN

被引：48

作者：

RODRIGUEZSORIANO, J

UBETAGOYENA, M

VALLO, A

机构：

[1] Division of Paediatric Nephrology, Department of Paediatrics, Hospital Infantil de Cruces and Basque University School of Medicine, Bilbao

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 02期

关键词：

Aldosterone; Hypoaldosteronism; Potassium; Pseudohypoaldosteronism; Renal potassium excretion;

D O I：

10.1007/BF00858819

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The present investigation was designed to validate the usefulness of transtubular potassium (K) concentration gradient (TTKG) as an indicator of aldosterone bio-activity in infants and children. TTKG was calculated by the formula: {Mathematical expression} We compared this index with fractional K excretion (FEK) and urine K concentration to urine sodium (Na) concentration ratio (UK/UNa) in 473 normal children aged 1 month-15 years. Values of TTKG followed a non-gaussian distribution (median, 6.3; 3rd centile, 4.1; 97th centile, 13.4). TTKG in infants (n=108; median, 7.8) was significantly higher than in children (n=365; median, 6.0). TTKG correlated directly with FEK and UK/UNa. Indices of K excretion were also assessed in 13 patients with hypo- and pseudohypoaldosteronism. TTKG values varied between 1.6 and 4.1 and were all below the 3rd percentile established for the age of the subject. We conclude that calculation of TTKG is an easy and sensitive method for the evaluation of mineralocorticoid action in distal and collecting tubules. © 1990 IPNA.

引用

页码：105 / 110

页数：6

共 34 条

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