TRANSLATIONAL EFFICIENCY - IRIDOVIRUS EARLY MESSENGER-RNAS OUTCOMPETE TOBACCO MOSAIC-VIRUS MESSAGE INVITRO

被引：2

作者：

CHINCHAR, VG

YU, W

机构：

[1] Department of Microbiology, University of Mississippi Medical Center, Jackson

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0006-291X(90)91599-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infection with the iridovirus, frog virus 3, results in the rapid inhibition of host cell protein synthesis and is correlated with activation of an eIF-2 kinase. Because phosphorylation of eIF-2 inhibits ternary complex formation and thus reduces the overall level of translation, it has been suggested that frog virus 3 messages escaped translational shut-off by outcompeting host messages for the remaining translational capacity of the cell. In this report, we show that frog virus 3 messages were more translationally competitive than highly efficient tobacco mosaic virus transcripts based on their relative resistance to inhibitors of initiation. This result strengthens the suggestion that the selective translation of frog virus 3 transcripts in virus-infected cells may be a reflection of their enhanced competitiveness. © 1990.

引用

页码：1357 / 1363

页数：7

共 22 条

[1]

CHINCHAR VG, 1989, VIRUS RES, V14, P207

[2] FROG VIRUS-3-MEDIATED TRANSLATIONAL SHUT-OFF - FROG VIRUS-3 MESSAGES ARE TRANSLATIONALLY MORE EFFICIENT THAN HOST AND HETEROLOGOUS VIRAL MESSAGES UNDER CONDITIONS OF INCREASED TRANSLATIONAL STRESS [J].