TEMPERATURE-DEPENDENCE OF ELECTRIC-FIELD EFFECTS ON NA,K-ATPASE

被引:11
作者
BLANK, M
SOO, L
机构
[1] Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032
来源
BIOELECTROCHEMISTRY AND BIOENERGETICS | 1992年 / 28卷 / 1-2期
关键词
D O I
10.1016/0302-4598(92)80020-H
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have shown that the effect of alternating currents (a.c.) on Na,K-ATPase varies with temperature, and that the observations can be explained by assuming a simple theoretical model of changes in the ion binding to the activation sites due to an imposed alternating electric field. Previous observations showing that the effect of an electric field on the enzyme can lead to either an enhancement or a decrease in enzyme activity, depending upon the initial activity, also appears to be true when the enzyme activity is varied by changing the temperature. This suggests very strongly that the mechanism of action of a.c. is the result of changing in ion binding and not changes in lipid phase structure.
引用
收藏
页码:291 / 299
页数:9
相关论文
共 13 条
[1]   THE EFFECTS OF ALTERNATING CURRENTS ON NA,K-ATPASE FUNCTION [J].
BLANK, M ;
SOO, L .
BIOELECTROCHEMISTRY AND BIOENERGETICS, 1989, 22 (03) :313-322
[2]   ION ACTIVATION OF THE NA,K-ATPASE IN ALTERNATING CURRENTS [J].
BLANK, M ;
SOO, L .
BIOELECTROCHEMISTRY AND BIOENERGETICS, 1990, 24 (01) :51-61
[4]  
BLANK M, 1992, FASEB J, V6, P2734
[5]  
BLANK M, IN PRESS BIOELECTROM
[6]   THALLIUM ACTIVATION OF (NA+-K+)-ACTIVATED ATPASE OF RABBIT KIDNEY [J].
BRITTEN, JS ;
BLANK, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 159 (01) :160-&
[7]   SODIUM PLUS POTASSIUM TRANSPORT ADENOSINE TRIPHOSPHATASE ACTIVITY IN KIDNEY [J].
KINSOLVING, CR ;
BEAVER, DL ;
POST, RL .
JOURNAL OF CELLULAR AND COMPARATIVE PHYSIOLOGY, 1963, 62 (01) :85-&
[8]  
LIU DS, 1990, J BIOL CHEM, V265, P7260
[9]   RELIPIDATION OF DELIPIDATED NA,K-ATPASE - ANALYSIS OF COMPLEX-FORMATION WITH DIOLEOYLPHOSPHATIDYLCHOLINE AND WITH DIOLEOYLPHOSPHATIDYLETHANOLAMINE [J].
OTTOLENGHI, P .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1979, 99 (01) :113-131
[10]   FREQUENCY-DEPENDENCE OF CATALYZED-REACTIONS IN A WEAK OSCILLATING FIELD [J].
ROBERTSON, B ;
ASTUMIAN, RD .
JOURNAL OF CHEMICAL PHYSICS, 1991, 94 (11) :7414-7419